Delayed endothelialization and inflammatory responses are two major obstacles that drug-eluting stents (DES) face in promoting vascular healing. This paper reports a biomimetic nanozyme strategy to tackle this issue. First, we designed a stable glutathione peroxidase (GPx) mimicking nanozyme with a diselenide-polyphenol network structure and anchored it onto the stent. Then, using its reversible interactions with polyphenols, we efficiently loaded the thrombin inhibitor bivalirudin onto the nanozyme. This nanozyme has strong GPx activity, can controllably generate nitric oxide (NO), and release bivalirudin on demand. The synergistic effect of NO and bivalirudin effectively inhibits thrombin activity, prevents platelet activation, and thereby reduces thrombosis and related inflammatory responses. In vitro pathological model cell studies show that the nanozyme-engineered stent can specifically inhibit smooth muscle cell (SMC) proliferation, regulate macrophage polarization, and promote repair and proliferation of endothelial cells. As a result, this stent can promote rapid endothelialization and vascular healing, helping to prevent restenosis in rabbit and pig models.

Reference Info:

Advanced Materials (IF 29.1)

Pub Date: 2026-10-05,

DOI: 10.1002/adma.75212

We focus on custom functional materials in the field of nanomedicine. Based on your experimental needs, we can develop biofunctional nanomaterials, adjusting material structure, particle size, and surface modification, and provide full characterization testing. The plan can be repeatedly optimized with full technical support, supporting research projects related to targeted delivery, bioimaging, nanodiagnostics, and therapy. Feel free to provide your requirements, and we’ll evaluate customized solutions.

Engineer Zhang: 17715390137
Engineer Chen: 18914047343