This study developed a PLLA-ZnO microenvironment-responsive piezoelectric interface, exposing aligned ZnO nanowires on the surface of electrospun PLLA fibers, combining enhanced piezoelectric response, nano-morphology, and acid-responsive Zn²⁺ release. This interface is designed to coordinate antibacterial action, immune regulation, and bone formation, addressing the conflict between infection control and bone regeneration in implant-related bone infections. In vitro, it shows broad-spectrum antibacterial effects, promotes pro-healing polarization of macrophages, and supports mesenchymal stem cell osteogenesis; in a rat model, it inhibits bacterial colonization, reduces inflammation, promotes bone regeneration and integration, and is biocompatible.

Original Source:

Science Bulletin

Pub Date: 2026-10-01

DOI: 10.1016/j.scib.2026.10.008

Changxu Chen, Jianfeng Sun, Zijian Wang, Jiaxuan Li, Xiaozhou Wen,

Xuqiao Zhao, Jinxi Liu, Yong Chen, Yilin Qi, Shuncheng Yao, Zhipeng Qu,

Engui Wang, Han Ouyang, Swee Hin Teoh, Xi Cui, Zhou Li

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