Chen Xiaoyuan/Yu Guocan/Wang Sheng et al. Angew: Nanotechnology-mediated pyrolysis for cancer treatment

Dan Wu from Zhejiang University of Technology, Professor Wang Sheng from Tianjin University, and researchers from NIH Yu Guocan and Chen Xiaoyuan from the United States reviewed the research on the application of nanotechnology-mediated pyroptosis in the field of cancer treatment.



Key points of this article:

(1) Pyroptosis is a unique form of programmed cell death (PCD), which is characterized by DNA fragmentation, chromatin condensation, cell swelling and leakage of cell contents, and it has also been confirmed It is closely related to human diseases such as inflammatory diseases and malignant tumors. In 2015, researchers discovered a new type of keratin D (GSDMD) protein and developed many strategies that can induce pyrolysis to treat cancer, including ions, small molecule drugs, and nanomaterials. Although there have been some reports on the close relationship between the mechanism of cell pyrolysis and various cancers, the research on the use of nanomedicine to induce cell pyrolysis to treat cancer has not yet been summarized.



(2) In the article, the author detailed the research progress in recent years using nanoparticles to cause cell pyrolysis to treat cancer, focusing on the main points of designing nanoparticles and their own advantages. Finally, the author also discusses the development of this emerging field. The prospects were looked forward to.



The following are some pictures and texts:

Abstract schematic




Pyrolysis pathway




Diagram of DAC demethylation process and immune activation process based on the pyroptosis pathway






Light-triggered pyroptosis








references:

Dan Wu. et al. Cell Death Mediated by Pyroptosis Pathway with the Help of Nanotechnology: New Prospects for Cancer Therapy. Angewandte Chemie International Edition. 2020

DOI: 10.1002/anie.202010281

https://onlinelibrary.wiley.com/doi/10.1002/anie.202010281
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