Shi Jianlin JACS: Iron-engineered nano-drugs for effective ascorbic acid tumor chemotherapy

Ascorbic acid is a polyhydroxy compound with a long history and has been widely regarded as an effective antioxidant. However, only in the past few decades has it gradually discovered its pro-oxidation properties in the presence of transition metal catalysts. This has attracted extensive attention from researchers in chemistry and biology, hoping to bring various practical applications such as anti-cancer treatments. To benefit.

In this work, Shi Jianlin, Shanghai Institute of Ceramics, Chinese Academy of Sciences, and others reported that hollow mesoporous silica nano-drugs supported by iron engineering and ascorbic acid catalyze the oxidation of ascorbic acid and the production of active oxygen for effective tumors Chemotherapy.

Key points of this article:

1) The -Si-O-Fe-hybrid framework of nanomedicine can not only achieve acid-triggered degradation and ascorbic acid release, but also provide a rich source of Fe ions, which can catalyze the oxidation of ascorbic acid, the formation of hydrogen peroxide, and the formation of hydrogen peroxide. The subsequent Fenton reaction.

2) The detailed chemical mechanism of the oxidation of ascorbic acid catalyzed by Fe3+ has been discussed in detail as two one-electron reaction processes. The first reaction process is the continuous capture of Fe3+ and O2 by ascorbic acid to form a metal-ascorbic acid-oxygen that is conducive to the generation of hydrogen peroxide. Ternary complex.

3) Both in vitro and in vivo results show that the anticancer effect of the composite nanomedicine catalyzed by the oxidation of ascorbic acid is significantly enhanced, which proves the high feasibility of this collaborative treatment concept. It is expected that this nano-drug design will benefit the future development of the ascorbic acid field.

references:

Bowen Yang, et al. Ascorbate Tumor Chemotherapy by An Iron-Engineered Nanomedicine-Catalyzed Tumor-Specific Pro-Oxidation, J. Am. Chem. Soc., 2020.

DOI: 10.1021/jacs.0c09984

https://doi.org/10.1021/jacs.0c09984

Source of information: Wonders

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