Tsinghua University/Peking Union Medical College Hospital Nanoscale: Light-responsive degradable mesoporous silica nanoparticles for drug delivery and lubrication to treat osteoarthritis

Associate researcher Zhang Hongyu of Tsinghua University and Feng Bin of Peking Union Medical College Hospital used azobenzene-modified mesoporous silica nanoparticles (bMSNs-AZO) and β-cyclodextrin-modified poly(2-methacryloxyethylphosphoryl) The supramolecular interaction between choline (CD-PMPC) constructs a bifunctional biodegradable mesoporous silica nanoparticle with light responsiveness.

Key points of this article:
(1) Visible light can effectively trigger the isomerization of azobenzene, thereby inducing the release of the drug after passing through the dermal tissue.



(2) In addition, the hydration layer formed by CD-PMPC on the surface of nanoparticles also has an important lubrication enhancement effect, which can further enhance the treatment of osteoarthritis.



references:
Weiwei Zhao. et al. Light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement for the treatment of osteoarthritis. Nanoscale. 2021
DOI: 10.1039/d0nr08887k
https://pubs.rsc.org/en/content/articlelanding/2021/nr/d0nr08887k#!divAbstract