IF 16! Reshaping the Tumor Microenvironment: Reviving Immunologically Cold Tumors and Driving a New Paradigm in Cancer Immunotherapy

已传文件：photo/1766454712.png This article selection

The treatment of solid tumors often faces significant challenges. These issues include low drug delivery efficiency due to the lack of specific targets and difficulty in penetrating tumors, as well as insufficient immune activation exacerbated by an immunosuppressive tumor microenvironment.This study introduces a biomimetic system that utilizes a fusion membrane (FM) composed of bacterial-derived outer membrane vesicles (OMVs) decorated with hyaluronidase and PD-L1 knockout cancer cell membranes (CCMs). Leveraging the affinity of OMVs for neutrophils, the FM can efficiently navigate to tumor sites.Hyaluronidase decoration further overcomes the fibrous matrix barrier, promoting the infiltration of immune cells and therapeutic drugs. Meanwhile, gene-edited CCM not only ensures precise homologous tumor targeting but also minimizes the introduction of exogenous immunosuppressive factors.Each component of FM provides abundant antigens, enhancing immunostimulation and addressing insufficient immune responses. In multiple tumor models, our results indicate that the FM system demonstrates superiority in tumor targeting, penetration, and immune activation.When combined with chemotherapy and immunotherapy, it significantly reduces tumor size and improves survival rates. This advanced biomimetic platform integrates precise targeting, efficient drug delivery, and potent immune stimulation, providing a promising approach for the treatment of solid tumors.

Original link

Remodeling the Tumor Microenvironment: An Emerging Paradigm for Reinvigorating Immunologically Cold Tumors and Advancing Cancer Immunotherapy
ACS Nano ( IF 16 )

Pub Date : 2025-12-18

DOI: 10.1021/acsnano.5c14644

Jia Zeng,  Xinning Fang,  Yuhan Li,  Qi Yan,  Yitong Li,  Han Yu,  Xiangyu Zhao,  Mengyuan Xu,  Zhenghong Wu,  Xiaole Qi