已传文件：photo/1768290138.png
The core highlight of this Nature Communications (2025, in press) report by Xu Feng/Xia Jingyan from the Second Affiliated Hospital of Zhejiang University School of Medicine is to make extracellular vesicles (EVs) of the natural microalgae "Chlorella" into inhalable cationic chitosan nanogels. And it is used in "mechanism-level synergy" with the cGAS inhibitor RU.521 for the treatment of radiation-induced lung injury (RILI). The author seized on the key pathological axis of early RILI over-activation of CGAS-STING triggered by DNA damage/cytoplasmic dsDNA: on the one hand, RU.521 directly brakes the CGAS-STING inflammatory cascade; On the other hand, Chlorella EVs are naturally rich in antioxidant enzymes such as SOD2 and CAT, as well as anti-inflammatory lipid components, which further counteract ROS/ oxidative stress and inflammatory amplification. In terms of material design, the positive charge of chitosan brings advantages in mucus adhesion and mucosal penetration, enhancing the efficiency of pulmonary retention and local delivery. Animal experiments have shown that it has both anti-inflammatory and anti-fibrotic effects, and has low systemic toxicity, emphasizing the engineering path of "safety, low cost and convertibility".
Relevant research focuses on Chlorella-derived extracellular vesicle-based nanogels to suppress cGAS-STING for treatment of radiation-induced lung injury
This chapter is not yet complete. You can move on：https://mp.weixin.qq.com/s/d0ed-zqE0ggWvac59CPEUQ
Reprint: Advances in Nanomedicine
