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Nanomaterials driven ferroptosis, by inducing iron overload and oxidative stress, offers a promising therapeutic strategy for combating antibiotic-resistant bacterial infections. However, bacterial metal transporters (MTPs) and antioxidant systems can reduce iron accumulation and lipid peroxidation, limiting the efficacy of iron-death-based therapies and promoting drug resistance. Single-atom and chiral nanomaterials, with their high atomic utilization and catalytic specificity, may provide an effective approach to overcome bacterial defense mechanisms, but this potential has not yet been exploited. In this study, we report the use of D-handed single-atom iron-carbon dot nanomaterials (DFe-NSC) for effective treatment of bacterial infections. Compared to the L-handed form (LFe-NSC), DFe-NSC exhibits significantly higher peroxidase (POD)-like and glutathione peroxidase (GPx)-like activities. The enhanced catalytic activity promotes the generation of reactive oxygen species (ROS) and the depletion of glutathione, disrupting the redox homeostasis of bacteria. More interestingly, DFe-NSC is more effective than LFe-NSC in regulating the expression and iron-regulating functions of MTPs (including Fur and FtnA). This will induce a large accumulation of intracellular Fe²⁺ and subsequent lipid peroxidation, thereby promoting the bactericidal effect of ferroptosis-like cell death. Therefore, in diabetic infection wounds and osteomyelitis models, DFe-NSC shows significantly enhanced antibacterial and anti-biofilm activities. This study introduces a chiral catalytic-MTP regulation strategy to induce ferroptosis-like death in bacteria, providing a promising alternative for the treatment of antibiotic-resistant infections. This research was published in Advanced Materials under the title "Chiral Single-Atom Nanozymes-Enabled ROS Catalysis and Metal Transport Regulation Cooperatively Induce Ferroptosis to Treat Bacterial Infections".
This study reports the design and preparation of chiral single-atom iron carbon dot nanoenzyme (DFe-NSC) with chiral selectivity for ROS catalysis and MTP regulatory function, aiming to achieve effective antibacterial treatment by inducing ferroptosis-like death.
Paper link (DOI): https://doi.org/10.1002/adma.202518810
This chapter is not yet complete. Reprinted from:https://mp.weixin.qq.com/s/yuQWvozlhAT_plqrVS4Qmw
