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Research Background
Skin wound healing is a highly coordinated physiological process involving precise regulation of multiple stages such as inflammation, proliferation, and remodeling. However, persistent inflammation, excessive oxidative stress, and impaired angiogenesis are the core pathological factors leading to healing disorders, especially common in chronic refractory wounds such as those associated with diabetes. These factors are interrelated, forming a vicious cycle: excessive reactive oxygen species (ROS) exacerbate tissue damage and maintain the inflammatory state; chronic inflammation inhibits the formation of new blood vessels, resulting in local hypoxia and insufficient nutrient supply, ultimately hindering tissue repair. Therefore, developing multifunctional bioactive materials that can synergistically regulate the inflammatory microenvironment, efficiently eliminate ROS, and actively promote angiogenesis has become a frontier need and significant challenge in this field.
Recently, a team led by Professor Liu Bin from the First Hospital of Jilin University, Wang Shun from the Second Affiliated Hospital of Zhengzhou University, and Wang Mengke from the Zhongyuan Nanomaterials Enzyme Laboratory, successfully developed a multifunctional nano-composite enzyme (CeMT) based on tannic acid functionalized cerium-based metal-organic frameworks. This CeMT material can simulate the cascade catalytic activity of superoxide dismutase (SOD) and catalase (CAT), effectively eliminating excessive ROS at the wound site, alleviating local hypoxia; at the same time, it can regulate the immune microenvironment (such as promoting macrophage polarization towards the repair phenotype and inhibiting the formation of neutrophil extracellular traps NETs), and synergistically promote angiogenesis and collagen deposition, thereby significantly accelerating the healing process of refractory skin wounds such as those associated with diabetes.
Research Contents
This study synthesized CeM nanoenzymes with SOD and CAT mimetic activities through solvothermal method, and further introduced tannic acid modification at room temperature to successfully construct CeMT composite nanomaterials. Structural characterization showed that CeMT was a microporous nanoparticle of approximately 200 nm, with high crystallinity and mixed valence states (Ce3+/Ce4+), and its surface was successfully loaded with TA. Performance verification demonstrated that CeMT can efficiently eliminate ROS such as O2•- and H2O2, exhibiting excellent cascade antioxidant enzyme mimetic activity, laying the foundation for managing diabetic wounds by eliminating ROS.
This chapter is not complete. Reprint:https://mp.weixin.qq.com/s/CwF5yCYgqr7QpkOD_z7JKQ
Original link:https://www.sciencedirect.com/science/article/pii/S2772950826000051?sessionid=
