Advanced Materials | Spatially Ordered Dual-Atom Nanozyme for Mimicking Substrate-Induced Conformational Locking in Natural Enzymes

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A spatially ordered Fe-Pd bimetallic nanozyme (o-FePd DAN) simulates substrate-induced conformational locking (SCL) through dynamic electronic coupling within the Cl-FeN3C-PdN3 sites. XAFS and DFT studies reveal a bridging structure-driven charge transfer pathway that effectively promotes adaptive regulation and selective catalysis, which is further applied to a POCT visual gene typing platform for HPV.