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This study investigated a novel composite hydrogel dressing for the efficient healing of infected wounds. To address challenges such as antibiotic resistance and the easy deactivation and poor retention of photosensitizers in traditional photodynamic therapy (PDT), the researchers developed a biomimetic mineralization strategy. This strategy encapsulates the small molecule photosensitizer chlorin e6 (Ce6) within magnesium phosphate nanoparticles (CMP NPs) to maintain its photodynamic activity.Subsequently, this mineralized nanoemulsion was combined with gelatin and natural moisturizing factors to construct the CMP/Gel hydrogel dressing. This dressing can prolong the local retention time of the photosensitizer in the wound and, through the released magnesium ions from its degradation, further exert multiple biological effects such as anti-inflammatory, antioxidant, and pro-angiogenic actions after PDT sterilization, thereby synergistically promoting the repair of infected wounds. This study provides a new approach for the development of multifunctional wound management materials, and the related results have been published in the materials science journal *Materials Today Bio*.
Material Development
Materials / Material
Small molecule photosensitizer Chlorin e6 (Ce6), magnesium ions and phosphate ions, gelatin, natural moisturizing factors.
Function / Function
Ce6 serves as the core of the photodynamic effect, producing reactive oxygen under light to kill bacteria. Magnesium phosphate nanoparticles act as a stable carrier for Ce6 and a magnesium ion reservoir. Gelatin forms the hydrogel framework, providing physical support and a sustained release platform. Natural moisturizing factors optimize the moist environment of the dressing, promoting cell migration and epithelialization.
Thoughts for Future Research
Based on the concepts of “inorganic mineralization encapsulating active molecules” and “metal ion synergistic therapy” in this study, future research could be deepened in two directions:
Expansion of the ion library functionality: Explore the encapsulation of other metal ions with clear biological activity (such as promoting bone formation or anti-tumor effects, e.g., strontium, zinc, copper) to construct an intelligent “mineral micro-library” capable of releasing multiple therapeutic ions on demand, applicable in fields such as bone repair or tumor therapy.
Development of responsive composite systems: Combine such mineralized nanoparticles with polymer materials sensitive to specific microenvironments (e.g., pH, enzymes, ROS) to design “sensing-response” type composite dressings that can detect pathological signals and intelligently release active components, achieving more precise and adaptive treatments.
Original Source
Journal Name: Materials Today Bio
Publication Date: February 23, 2026
DOI: 10.1016/j.mtbio.2026.102959
Research Team: Yongpeng Su, Shunying Liu, Mingdi He, Lingfei Li, Guihong Yang, Xiaohan Liu, Yiting Feng, Hui Tang, Lingbo Li, Jianxin Wu, Zhenglin Li, Yi Liang, Chao Qi, Kaiyong Cai, Xia Lei
