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Check the mobile phase: Ensure that the quality of the mobile phase is qualified. Use HPLC-grade solvents and make sure that the mobile phase has been filtered and degassed before use. If the mobile phase is contaminated or deteriorated, reconfigure it.
Check the detector: Ensure that the detector is working properly. Check if the light source is aged or contaminated. Replace the light source or clean the detector flow cell if necessary.
Check the instrument status: Ensure that the instrument is working properly. Check if the pump, column temperature box, etc. are functioning normally. If the seal ring of the pump is worn or the plunger rod is worn, replace the relevant components.
Check the chromatographic column: Column contamination or damage may cause an increase in baseline noise. Try to rinse the chromatographic column with a strong solvent. Replace the column if necessary.
Optimize operating parameters: Ensure that the flow rate, column temperature, and injection volume, etc. are set reasonably. Adjust the sensitivity of the detector appropriately to optimize the baseline noise.
