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The iron death strategy driven by nanoenzymes provides a new approach to combating antibiotic-resistant bacterial infections by inducing iron overload and oxidative stress. However, the bacterial metal transport proteins and antioxidant systems can effectively reduce iron accumulation and inhibit lipid peroxidation, which significantly limits the efficacy of iron death-based therapies and may even induce bacterial resistance. Single-atom nanoenzymes, with their maximum atomic utilization and uniform active center structure, exhibit unique advantages, and chiral regulation is expected to confer their catalytic specificity. How to use chiral single-atom nanoenzymes to synergistically regulate catalytic activity and bacterial metal homeostasis to overcome bacterial defense mechanisms remains a key issue that needs to be addressed in this field. This work was published in Advanced Materials under the title "Chiral Single-Atom Nanozymes-Enabled ROS Catalysis and Metal Transport Regulation Cooperatively Induce Ferroptosis to Treat Bacterial Infections".
