This study investigated a time-functional composite hydrogel scaffold for cranial defect repair, which can promote the regeneration of vascularized bone by sequentially regulating angiogenesis and osteogenesis. Traditional bone repair materials often serve as inert fillers and are difficult to dynamically coordinate the timing of different biological events during bone regeneration. This study addresses this challenge,Designed a composite hydrogel system based on silk fibroin

Original Source

Journal Name: Theranostics

Publication Date: January 1, 2026

DOI: 10.7150/thno.119835

Research Team: This study was conducted jointly by researchers Su Jiacan, Chen Juxiang, and others.