Zhang Xianzheng Chem. Soc. Rev of Wuhan University: Biomimetic functional material of cell primordium for enhancing cancer treatment

Professor Zhang Xianzheng from Wuhan University reviewed the research on cell primordium biomimetic functional materials in enhancing cancer treatment.


Key points of this article:

(1) Cell primordium functional materials combine the advantages of natural materials and nanotechnology, and have become an attractive cancer treatment drug. The cytoplasma has unique biological functions, such as long-term circulation in the body, tumor-specific targeting and immune regulation. In addition, synthetic nanomaterials with unique physical and chemical properties have also been widely used as drug carriers or anti-cancer agents for the treatment of cancer. Therefore, the combination of these two materials is expected to produce biomaterials with multiple functions and high biocompatibility, which can then achieve precise cancer treatment.



(2) This article reviews the research progress of materials with tumor treatment functions based on cell primordia in recent years; introduces the uniqueness of different cell protozoa, including bacteria, phages, cells, cell membranes and other biologically active substances Biological activity and function; At the same time, the author also discussed the strategy of combining it with synthetic materials, especially nanosystems to construct functionalized biological materials; finally, the author also looked forward to the future research directions in this field.



Some pictures and texts:



Different forms of cell raw materials and synthetic materials





Different strategies for designing biological/non-biological hybrids based on cell-based original biomimetic functional materials





Different treatment formulations of the nano-bacterial hybrid system can be used as functional materials for cancer treatment



references:

Guo-Feng Luo. et al. Cell primitive-based biomimetic functional materials for enhanced cancer therapy. Chemical Society Reviews. 2020

DOI: 10.1039/d0cs00152j

https://pubs.rsc.org/en/content/articlelanding/2020/cs/d0cs00152j#!divAbstract


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