Article information
First author: Wang Kaiyang
Corresponding Authors: Yan Xiaobing , Jia Yunfang
Organization: Nankai University, Hebei University
Research Background
As a key part of the realization of brain-like functional simulation, biological synapses have received extensive attention from researchers due to their excellent information transmission and processing capabilities. So far, scientists have achieved neuromorphological features such as neuro-synaptic plasticity, biotactile, reflex behavior, and habituation behavior through the use of programmable electronic signal regulation through artificial synaptic devices such as two-terminal memristors and three-terminal transistors. Related simulations. This means that artificial synaptic devices have great potential in simulating biological synapses and have played a key role in the development of neuromorphological chips. However, related studies have shown that the plastic behavior of synapses is produced at the third junction of neuroreceptors and neurotransmitters in biological synapses. The results obtained through programmable electronic signal regulation are still different from the real neurobiochemical reactions in the human body. Therefore, how to achieve relevant human neurobiochemical responses through artificial synaptic devices more realistically and reliably is of great significance to the functional development of neuromorphology chips.
Introduction to Articles
Based on this, Professor Jia Yunfang from Nankai University and Professor Yan Xiaobing from Hebei University published a research article entitled Neuro-Receptor Mediated Synapse Device Based on the Crumpled MXene Ti3C2Tx Nanosheets in the internationally renowned journal Advanced Functional Materials.
This paper proposes a new type of three-terminal artificial synaptic device mediated by neural receptors, which modifies the related neuron receptor at the solid-liquid interface of the newly constructed third terminal MXene-PBS And control the amount of neurotransmitter in the solution to achieve a biological simulation of synaptic plasticity.
Subsequently, the corrugated MXene nanosheets significantly improved the related electrical and sensitive properties of the device. The research results provide a new strategy for artificial synaptic devices in simulating biochemical neurotransmission, which is expected to promote the multi-functional integration and development of neuromorphology chips in learning and sensing.
Figure 1. Graphical abstract.
The main points of the article
Key point 1: The design of a new type of three-terminal neuroreceptor-mediated artificial synapse device. Synaptic plasticity behavior is the third terminal neuromodulator in biological synapses through neuroreceptors and neurotransmitters Produced by the reaction at the junction. In order to simulate this phenomenon, a third-end MXene-PBS electrode was introduced as a biomimetic neuromodulator in a double-ended MXene synapse device to prepare a new type of three-terminal artificial synapse Device, used in the bionic and simulation of biological synapse.
Key point 2: Electronic properties and performance improvement methods of NR-S devices The basic electrical properties of NR-S devices based on non-wrinkled and wrinkled MXene nanosheets are explored. The study found that, compared to the NR-S device using non-corrugated MXene, the HRS/LRS gap of the device based on corrugated nanosheets has increased significantly from 1.24 × 104 Ω to 7.02 × 104 Ω, and has a wider resistance adjustment space. In addition, the uneven state of the corrugated nanosheets will cause the ions in the surface electric double layer to be more dispersed than the non-corrugated nanosheets, and the Debye length will increase, making it more sensitive. It also proved that the reversible valence changes of Ti in MXene artificial synaptic devices can also be adjusted by using biological stimulation signals other than traditional electrical signals.
Key point 3: The sensing properties and neurosynaptic plasticity behavior triggered by NR-S devices are inspired by the way of biological synaptic signal transmission. The neural receptor is used for NR- by modifying the neural receptor at the third-end MXene-PBS electrode interface. Sensing characteristic test of S device. The study found that NR-S devices based on fold-type MXene nanosheets can produce resistivity changes at ultra-low neurotransmitter concentration after modifying neural receptors, which is 103 times lower than that based on non-folding NR-S device of type MXene nanosheet. And with the increase of ACh content , the change of device conductivity shows an increasing trend. The sensing characteristics of NR-S-based devices are similar to the plastic behavior of nerve synapses.
Key point 4: NR-S device s neurodestructive behavior and muscle weakness detection application After the surface layer of the electrode interface modified with neuroreceptors is modified with the corresponding destructive autoreceptor antibody , as the amount of antibody increases, The sensor range of NR-S devices for neurotransmitters is reduced, and the sensitivity for detection of neurotransmitters is reduced. This result is similar to the neurodestructive behavior of neuromuscular transmission disorder, and it also provides a feasible strategy for the detection of myasthenia in the future.
Foresight
In general, this work provides an important device construction strategy for the bionic simulation of neurobiochemistry in biological neuronal systems. It provides new means and application prospects for artificial synaptic devices in the field of biosensing, and provides an important reference for the diversified development of neuromorphic chips.
Article link
Neuro-Receptor Mediated Synapse Device Based on the Crumpled MXene Ti3C2Tx Nanosheetshttps://onlinelibrary.wiley.com/doi/10.1002/adfm.202104304
Brief Introduction of Communication Author
Professor Yan Xiaobing. Professor and doctoral supervisor of the School of Electronic Information Engineering of Hebei University. In recent years, he has been committed to the research and development of the key components of brain-like chips, memristor devices and systems, and has successively won the National Major Talent Project-Ministry of Education Young Yangtze River Scholar, Ministry of Education Huo Yingdong Young Teacher Award, Hebei Province Youth Science and Technology Award, Hebei Province Youth May 4th Medal, Hebei Province Youth Top Talent, Hebei Province Three-Three-Three Talent Two-level Title, Hebei Province Outstanding Youth, Baoding City Science and Technology Progress Award, etc. He has published more than 100 papers in the top international authoritative journals Nature Nanotechnology, Advanced Materials, Nature Communications, etc., among which more than 20 papers have an impact factor of >10. With a total of 40/30 national invention patent applications/authorizations as the first author, and 1 US patent, it provides technical reserves for the national stuck neck problem. It is affirmed and cited by domestic and foreign counterparts. In 2019, it was rated as the top 2% in the world. the scientist. Currently serving as the guest editor of Frontiers in Neuroscience magazine, a senior member of IEEE in the United States, and reviewer of international authoritative journals such as Advance Materials and ACS Nano.
Jia Yunfang Professor. Professor, Doctoral Supervisor, Department of Microelectronic Engineering, School of Electronic Information and Optical Engineering, Nankai University, Research Field: Biomedical Electronic Engineering. He obtained his Ph.D. degree from Nankai University in 2004, engaged in post-doctoral research at Nankai University School of Life Sciences in 2005-2007, and was a visiting scholar at the National Scholarship Council of Phillips Marburg University in Germany from 2009-2010. He has successively won the first prize of Tianjin Science and Technology Progress Award, the third prize of Tianjin Science and Technology Progress Award, and the director of Tianjin Biomedical Engineering Society.
Introduction to the first author
Wang Kaiyang is a PhD student in the School of Electronic Information and Optical Engineering, Nankai University. He graduated from the research group of Professor Yan Xiaobing of Hebei University and has published 3 research papers in Nano Energy, Small, Adv. Electron. Mater as the first author. The main research direction at this stage is the design and application of new biochemical sensors based on nerve synapses. He was awarded the 2020 Hebei Province Excellent Masters Graduate.
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