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Worldwide, wound infections caused by drug-resistant bacteria pose a huge challenge to clinical treatment. To address this challenge, Professor Wang Xianwen from Anhui Medical University designed a novel three-component hydrogel (TiO/CIP/SilMA). This hydrogel ingeniously combines titanium dioxide (TiO) nanosheets, the antibiotic ciprofloxacin (CIP), and silk fibroin methacrylate (SilMA). The core treatment strategy is the synergistic effect of photothermal therapy (PTT) and antibiotics. Under the irradiation of near-infrared light (NIR), titanium dioxide nanosheets in the hydrogel generate heat, which can physically damage the cell membranes of bacteria and increase their permeability. This not only directly kills the bacteria but also creates conditions for antibiotics (CIP) to enter the interior of the bacteria, thereby enhancing the bactericidal effect. Deeper research has found that this combined therapy works by interfering with the key life activities within the bacteria. Transcriptomic analysis indicates that it can down-regulate the "two-component signal transduction system" (such as SaeR/SaeS) and energy metabolism pathways (such as oxidative phosphorylation) of bacteria, thereby weakening their adaptability and survival ability to the environment. This hydrogel not only effectively combates drug-resistant bacteria but also accelerates tissue regeneration by continuously releasing drugs, reducing inflammation and promoting new blood vessel formation, providing a promising new treatment option for drug-resistant wound infections. the relevant research focuses on TiO/CIP/SilMA hydrogels promoting the repair of infected wounds by interfering with bacterial signaling and energy metabolism was published in Cell Biomaterials.
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