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Breakthrough development of MOFs/COFs composite nano-medical hydrogel, integrating three core functions: tumor-targeted delivery, catalytic therapy, and intelligent responsiveness! Using a pH/enzyme dual-responsive MOFs carrier to precisely load chemotherapy drugs like doxorubicin and anti-PD-1 antibodies, achieving spatiotemporal controlled release triggered by the tumor microenvironment (TME) acidic conditions, reducing toxicity by 70% and enhancing efficacy threefold! Innovative COFs-based nanozyme hydrogel, equipped with Fe³⁺/Cu²⁺ active sites,Fenton-like reaction catalytic efficiency increased fivefold, combined with photothermal therapy (PTT) to achieve CDT-PTT synergistic anti-tumor effects, with a tumor killing rate exceeding 90%! Exclusive antibacterial MOF hydrogel coating loaded with silver nanoparticles and vancomycin, after surface modification of orthopedic implants, achieves a 99% inhibition rate of drug-resistant bacteria and reduces biofilm formation by 80%! The technology spans cutting-edge fields including tumor immunotherapy, chemodynamic therapy, nanozyme catalysis, and smart antibacterial applications, suitable for cancer treatment, postoperative infection prevention, chronic disease management, and other scenarios, redefining precision medicine with intelligent hydrogel materials.
