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The progression of inflammatory diseases such as osteoarthritis (OA), acute liver injury (ALI), and acute kidney injury (AKI) is closely related to the ferroptosis caused by oxidative-reductive imbalance. Although Fe atom nanoenzymes have promising prospects in inhibiting ferroptosis and treating inflammation, the common Fe-N4 configuration limits the catalytic performance of Fe atom nanoenzymes. This study innovatively designs and constructs a nitrogen-oxygen doped bamboo-like carbon nanotube (FeMnDA/BCNT) loaded with Fe and Mn, and encapsulates the macrophage membrane to obtain a multifunctional iron-manganese dual-atom nanoenzyme ([MM]FeMnDA/BCNT). This nanoenzyme achieves the anchoring of iron-manganese dual-atom nanoenzymes on the carbon nanotube through spatial confinement pyrolysis, endowing it with efficient SOD, CAT, and GPx-like multi-enzyme activities. Its unique Fe and Mn 3dz² orbital alignment structure promotes electron transfer and free radical adsorption, significantly enhancing catalytic efficiency; at the same time, the macrophage membrane provides its targeting performance. The functionalized nanoenzyme can target inflammation, eliminate ROS and inhibit cell ferroptosis, demonstrating great potential in various inflammatory diseases.
Research team: Zhong Jingping team from Guangxi Medical University
Published in: Advanced Materials (Impact Factor: 26.8)
Publication date: March 25, 2026
Article Title: Reconstructing the aligned d orbital energy levels in FeMn bimetallic nanoenzymes to inhibit cell pyroptosis and effectively alleviate inflammatory diseases
Reengineering the Energy Levels of Aligned D-Orbitals in FeMn Dual-Atom Nanozyme Alters Pyroptosis and Effectively Alleviates Inflammatory Diseases
DOI: https://doi.org/10.1002/adma.72857
